Article
Alterations of K-ras, p53, and erbB-2/neu in human lung adenocarcinomas.
The Journal of thoracic and cardiovascular surgery - 1 Feb 1994
Bongiorno P F, Whyte R I, Lesser E J, Moore J H, Orringer M B, Beer D G
Abstract excerpt
The development of human adenocarcinoma of the lung involves multiple genetic changes including activation of oncogenes and loss of tumor suppressor genes. Patients whose lung tumors contain K-ras oncogene mutation, accumulation of the protein product of the tumor suppressor gene p53, or erbB-2/n...
Topics
- Adenocarcinoma
- Biomarkers, Tumor
- Codon
- ErbB Receptors
- Gene Expression
- Genes, ras
- Humans
- Lung Neoplasms
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogenes
- Receptor, ErbB-2
- Tumor Suppressor Protein p53