p53 and ras gene mutations in lung cancer: implications for smoking and occupational exposures.

doi:10.1097/00043764-199501000-00010

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Article

p53 and ras gene mutations in lung cancer: implications for smoking and occupational exposures.

Journal of occupational and environmental medicine - 1 Jan 1995

Husgafvel-Pursiainen K, Ridanpää M, Anttila S, Vainio H

Abstract excerpt

This paper reviews mutational activation of ras oncogenes and inactivation of the p53 tumor suppressor gene in human lung cancer. We discuss the frequency, type, and location of mutations in these genes in relation to known etiological factors for lung cancer. The most studied examples of these a...

Topics

Genes, p53
Genes, ras
Humans
Lung Neoplasms
Molecular Epidemiology
Mutation
Occupational Exposure
Prevalence
Smoking

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