Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners.

doi:10.1016/0140-6736(92)90866-2

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Article

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners.

Lancet (London, England) - 7 Mar 1992

Vähäkangas K H, Samet J M, Metcalf R A, Welsh J A, Bennett W P, Lane D P, Harris C C

Abstract excerpt

Radon increases the risk of lung cancer in smoking and non-smoking underground miners. To investigate the mutational spectrum associated with exposure to high levels of radon, we sequenced exons 5-9 of the p53 tumour suppressor gene and codons 12-13 of the Ki-ras protooncogene in 19 lung cancers...

Topics

Aged
Base Sequence
Carcinoma
Chromosome Deletion
Codon
DNA, Neoplasm
Genes, p53
Genes, ras
Humans
Lung Neoplasms
Middle Aged
Mining
Molecular Sequence Data
Mutation
Neoplasms, Radiation-Induced
Occupational Diseases
Polymerase Chain Reaction
Radon

Source

Open in PubMed

Identifiers

PMID: 1347094
DOI: 10.1016/0140-6736(92)90866-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1347094-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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