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Article

Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI.

Atherosclerosis - 1 Aug 2011

Peters Bas J M, Pett Helmi, Klungel Olaf H, Stricker Bruno H Ch, Psaty Bruce M, Glazer Nicole L, Wiggins Kerri L, Bis Josh C, de Boer Anthonius, Maitland-van der Zee Anke-Hilse

Abstract excerpt

Genetic variability has been shown to affect statin responsiveness. Participants from the Utrecht Cardiovascular Pharmacogenetics (UCP) studies were enrolled from a population-based registry of pharmacy records linked to hospital discharge records (PHARMO) to investigate tagging SNPs within candidate genes involved in the cholesterol lowering pathway for modification of the effectiveness of statins in reducing...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 5
Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypercholesterolemia

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to PPAR gamma

Share to Proprotein Convertase 9

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Share to Scavenger Receptors, Class B

Source

Open in PubMed Open full text

Identifiers

PMID: 21741043
DOI: 10.1016/j.atherosclerosis.2011.06.023
PMCID: PMC3465613

Genes

ABCA1
ABCG5
LIPC
LRP1
PCSK9
PPARG
SCARB1
SOAT1

Variants

rs10888896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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