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Article

Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1.

Pharmacogenetics and genomics - 1 Jul 2008

Oswald Stefan, König Jörg, Lütjohann Dieter, Giessmann Thomas, Kroemer Heyo K, Rimmbach Christian, Rosskopf Dieter, Fromm Martin F, Siegmund Werner

Abstract excerpt

OBJECTIVES: Genetic variability in hepatic uptake was recently shown to influence the disposition and cholesterol-lowering effects of statins. Ezetimibe, an inhibitor of the intestinal cholesterol uptake protein Niemann-Pick C 1 like 1, is another drug for which genetic polymorphisms of hepatic organic anion transporting polypeptides (OATPs) are expected to be of clinical relevance because ezetimibe undergoes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18551036
DOI: 10.1097/FPC.0b013e3282fe9a2c

Genes

ABCB1
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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