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Article

A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 2 Jan 2006

Oswald Stefan, Scheuch Eberhard, Cascorbi Ingolf, Siegmund Werner

Abstract excerpt

Ezetimibe (Ezetrol) is a novel cholesterol lowering drug which disposition is not fully understood in man. We developed a selective and high-sensitive assay to measure serum concentration-time profiles, renal and fecal elimination of ezetimibe in pharmacokinetic studies. Ezetimibe glucuronide, the major metabolite of ezetimibe was determined by enzymatic degradation to the parent compound. Ezetimibe was measured...

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Anticholesteremic Agents
Azetidines
Chromatography, Liquid
Ezetimibe
Liver-Specific Organic Anion Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mass Spectrometry

Organic Anion Transporters

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PMID: 16280261
DOI: 10.1016/j.jchromb.2005.10.034

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