Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCB1 pharmacogenetics: progress, pitfalls, and promise.

Clinical pharmacology and therapeutics - 1 Feb 2007

Chinn L W, Kroetz D L

Abstract excerpt

In 1976, Juliano and Ling(1) reported expression of a 170 kDa protein in colchicine-resistant Chinese hamster ovary (CHO) cells that was absent in drug-sensitive cells. Because this protein altered cellular permeability to colchicine, the authors named it P-glycoprotein (P-gp).(1) P-gp overexpression was described in tumor samples and leukemic cells.(2) High homology with bacterial transporters suggested that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomedical Research

Share to ABCB1 gene

Share to Genetic Predisposition to Disease

Share to Organic Anion Transporters

Share to Pharmacogenetics

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 17259950
DOI: 10.1038/sj.clpt.6100052

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCB1 pharmacogenetics: progress, pitfalls, and promise.PMID 17259950Read ↗

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2Semantic proximity Read ↗

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.Semantic proximity Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

The Role of ABC Transporters in Clinical PracticeSemantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).Semantic proximity Read ↗

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Semantic proximity Read ↗

[MDR1 (ABCB1) gene encoding glycoprotein P (P-gp), a member of ABC transporter superfamily: consequences for therapy and progression of neoplastic diseases].Semantic proximity Read ↗

P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations.Semantic proximity Read ↗

Pharmacogenomic importance of ABCG2.Semantic proximity Read ↗

Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)Semantic proximity Read ↗

Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.