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Article

Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort.

Pharmacogenetics and genomics - 1 Jan 2015

Meyer zu Schwabedissen Henriette E, Albers Martin, Baumeister Sebastian E, Rimmbach Christian, Nauck Matthias, Wallaschofski Henri, Siegmund Werner, Völzke Henry, Kroemer Heyo K

Abstract excerpt

BACKGROUND: The efficacy of statins, which are used commonly in primary and secondary prevention of cardiovascular diseases, shows a wide range of interindividual variability. Genetic variants of OATP1B1, a hepatic uptake transporter, can modify access of statins to its therapeutic target, thereby potentially altering drug efficacy. We studied the impact of genetic variants of OATP1B1 on the lipid-lowering...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25379722
DOI: 10.1097/FPC.0000000000000098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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