Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New insights into the genetic regulation of intestinal cholesterol absorption.

Gastroenterology - 1 Aug 2005

Lammert Frank, Wang David Q-H

Abstract excerpt

The small intestine is a unique organ providing dietary and reabsorbed biliary cholesterol to the body. However, the molecular mechanisms whereby cholesterol is absorbed have not yet been fully understood. Recent research suggests that the newly identified Niemann-Pick C1-like 1 protein (NPC1L1) is expressed at the apical surface of enterocytes and plays a critical role in the absorption of intestinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol
Share to Hypercholesterolemia
Share to Intestinal Absorption

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestine, Small

Share to Membrane Transport Proteins

Share to Risk Assessment

Share to Sensitivity and Specificity

Share to Severity of Illness Index

Source

Identifiers

PMID: 16083725
DOI: 10.1016/j.gastro.2004.11.017

Genes

ABCG5
ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New insights into the genetic regulation of intestinal cholesterol absorption.PMID 16083725Read ↗

A SNP of NPC1L1 affects cholesterol absorption in Japanese.Semantic proximity Read ↗

NPC1L1: evolution from pharmacological target to physiological sterol transporter.Semantic proximity Read ↗

Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.Semantic proximity Read ↗

Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?Semantic proximity Read ↗

Genetic variation and intestinal cholesterol absorption in humans: A systematic review and a gene network analysis.Semantic proximity Read ↗

High cholesterol absorption: A risk factor of atherosclerotic cardiovascular diseases?Semantic proximity Read ↗

Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers.Semantic proximity Read ↗

In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers.Semantic proximity Read ↗

Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterolSemantic proximity Read ↗

A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.Semantic proximity Read ↗

The niemann-pick disease genes; regulators of cellular cholesterol homeostasis.Semantic proximity Read ↗

Insights from human congenital disorders of intestinal lipid metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.