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Article

Fexofenadine pharmacokinetics are associated with a polymorphism of the <i>SLCO1B1</i> gene (encoding OATP1B1)

2 Mar 2005

Abstract excerpt

The H1-receptor antagonist fexofenadine is a P-glycoprotein substrate [1]. However, the effects of genetic polymorphisms of the MDR1 (ABCB1) gene, which codes for P-glycoprotein on the disposition of fexofenadine are unclear [2, 3]. In addition, fexofenadine is a substrate of the intestinal uptake transporters organic anion transporting polypeptide 1A2 (OATP1A2, OATP-A) and 2B1 (OATP2B1, OATP-B) [1, 4]. Fruit...

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Identifiers

PMID: 15842561
DOI: 10.1111/j.1365-2125.2005.02354.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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