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Mixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Sept 2016

Lu Xue-Feng, Zhou Yang, Bi Kai-Shun, Chen Xiao-Hui

Abstract excerpt

1. Pravastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor used for the treatment of hyperlipidaemia. This study aims to investigate the effects of genetic polymorphisms in OATP1B1, BCRP and NTCP on pravastatin population pharmacokinetics in healthy Chinese volunteers using a non-linear mixed-effect modelling (NONMEM) approach. A two-compartment model with a first-order absorption and...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26744986
DOI: 10.3109/00498254.2015.1130881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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