Article
Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2015
Peng Kuan-wei, Bacon James, Zheng Ming, Guo Yingying, Wang Michael Zhuo
Abstract excerpt
Hepatic OATPs 1B1, 1B3 and 2B1, as well as P-gp, play important roles in regulating liver uptake and biliary excretion of drugs. The intrinsic ethnic variability in OATP1B1-mediated hepatic uptake of statins has been proposed to underlie the ethnic variability in plasma exposures of statins between Caucasians and Asians. Using a targeted quantitative proteomic approach, we determined hepatic protein...
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