Article
Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2011
Choi Min-Koo, Shin Ho Jung, Choi Young-Lim, Deng Jian-Wei, Shin Jae-Gook, Song Im-Sook
Abstract excerpt
The purpose of this study was to investigate the effect of genetic variations in organic anion-transporting polypeptide 1B1 (OATP1B1) and Na(+)/taurocholate co-transporting polypeptide (NTCP) on the uptake of various statins having different affinities for these transporters. The functional activities and simultaneous expression of NTCP and OATP1B1 were confirmed by the uptake of taurocholate and...
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