Article
BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.
Development (Cambridge, England) - 1 Aug 2008
Mine Naoki, Anderson Ryan M, Klingensmith John
Abstract excerpt
In mouse, left-right (L-R) patterning depends on asymmetric expression of Nodal around the node, leading to Nodal expression specifically in the left lateral plate mesoderm (LPM). Bone morphogenetic protein (BMP) signaling is also involved, but the mechanistic relationship with Nodal expression remains unclear. We find that BMP signal transduction is higher in the right LPM, although Bmp4, which is required for...
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