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Article

BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.

Genes & development - 1 Nov 2008

Furtado Milena B, Solloway Mark J, Jones Vanessa J, Costa Mauro W, Biben Christine, Wolstein Orit, Preis Jost I, Sparrow Duncan B, Saga Yumiko, Dunwoodie Sally L, Robertson Elizabeth J, Tam Patrick P L, Harvey Richard P

Abstract excerpt

Bistability in developmental pathways refers to the generation of binary outputs from graded or noisy inputs. Signaling thresholds are critical for bistability. Specification of the left/right (LR) axis in vertebrate embryos involves bistable expression of transforming growth factor beta (TGFbeta) member NODAL in the left lateral plate mesoderm (LPM) controlled by feed-forward and feedback loops. Here we provide...

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Source

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Identifiers

PMID: 18981480
DOI: 10.1101/gad.1682108
PMCID: PMC2577791

Genes

NODAL
SMAD4
SMAD1
FOXH1
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.PMID 18981480Read ↗

BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.Semantic proximity Read ↗

Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries.Semantic proximity Read ↗

Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.Semantic proximity Read ↗

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.Semantic proximity Read ↗

Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.Semantic proximity Read ↗

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.Semantic proximity Read ↗

Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry.Semantic proximity Read ↗

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