Article
The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.
Developmental biology - 15 Dec 2001
Stottmann R W, Anderson R M, Klingensmith J
Abstract excerpt
Here we investigate the roles of the Bone Morphogenetic Protein (BMP) antagonists Chordin and Noggin in development of the mandible, which is derived from the first branchial arch (BA1). Both genes are expressed in the pharynx during early mandibular outgrowth and later in the mandibular process. Mice mutant for either Nog or Chd have only mild mandibular defects; however, pups of the genotype Chd(-/-);Nog(+/-)...
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