Article
Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.
Development (Cambridge, England) - 1 Oct 2011
Lenhart Kari F, Lin Shin-Yi, Titus Tom A, Postlethwait John H, Burdine Rebecca D
Abstract excerpt
Left-right (L/R) patterning is crucial for the proper development of all vertebrates and requires asymmetric expression of nodal in the lateral plate mesoderm (LPM). The mechanisms governing asymmetric initiation of nodal have been studied extensively, but because Nodal is a potent activator of its own transcription, it is also crucial to understand the regulation required to maintain this asymmetry once it is...
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