Article
Synergistic interaction between Gdf1 and Nodal during anterior axis development.
Developmental biology - 15 May 2006
Andersson Olov, Reissmann Eva, Jörnvall Henrik, Ibáñez Carlos F
Abstract excerpt
Growth and Differentiation Factor 1 (GDF-1) has been implicated in left-right patterning of the mouse embryo but has no other known function. Here, we demonstrate a genetic interaction between Gdf1 and Nodal during anterior axis development. Gdf1-/-;Nodal+/- mutants displayed several abnormalities that were not present in either Gdf1-/- or Nodal+/- single mutants, including absence of notochord and prechordal...
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