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Article

DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.

Cancer epidemiology - 1 Apr 2012

Reeves Stuart G, Meldrum Cliff, Groombridge Claire, Spigelman Allan, Suchy Janina, Kurzawski Grzegorz, Lubinski Jan, Scott Rodney J

Abstract excerpt

DNA repair plays a pivotal role in maintaining genomic integrity with over 130 genes involved in various repair pathways that include base excision repair, nucleotide excision repair, double strand break repair and DNA mismatch repair. Polymorphisms within genes that are involved in these processes have been widely reported to be associated with cancer susceptibility in an extensive range of malignancies that...

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Source

Identifiers

PMID: 21974800
DOI: 10.1016/j.canep.2011.09.003

Genes

BRCA2
MLH1
MSH2
MSH3
OGG1
XRCC1
XRCC2
XRCC3

Provenance

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