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Article

Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review.

American journal of epidemiology - 15 Nov 2002

Mitchell R J, Farrington S M, Dunlop M G, Campbell H

Abstract excerpt

Evidence to support a role for the mismatch repair genes human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2) in the etiology of colorectal cancer has come from linkage analysis, segregation studies, and molecular biologic analysis. More recently, carriers of potentially pathogenic mutations in the hMLH1/hMSH2 genes have consistently been shown to be at a greatly increased risk of developing colorectal...

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Identifiers

PMID: 12419761
DOI: 10.1093/aje/kwf139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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