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Article

Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?

Mutation research - 15 Dec 2008

Tulupova E, Kumar R, Hanova M, Slyskova J, Pardini B, Polakova V, Naccarati A, Vodickova L, Novotny J, Halamkova J, Hemminki K, Vodicka P

Abstract excerpt

The Czech Republic presents one of the highest incidences of colorectal cancer in the world. We genotyped 10 single nucleotide polymorphisms in five DNA mismatch repair genes in 614 colorectal cancer cases and 614 matched controls from this country. The carriers of T-allele of the hMSH6-556G>T polymorphism were at increased risk of colorectal cancer (OR 1.29; 95% CI 1.02-1.62). The stratification of data showed...

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PMID: 18851982
DOI: 10.1016/j.mrfmmm.2008.09.005

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