Article
Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer.
Journal of cancer research and clinical oncology - 1 Jan 2007
Chaksangchaichot P, Punyarit P, Petmitr S
Abstract excerpt
PURPOSE: To detect the hMSH2, hMSH6 and hMLH1 DNA mismatch repair gene mutations and microsatellite instability in somatic colorectal cancer. PATIENTS AND METHODS: The mutations of hMSH2, hMSH6, and hMLH1 genes, including microsatellite instability of BAT-26, BAT-40, D2S123, D5S346 and D17S250 were analyzed in 31 patients with colorectal. RESULTS: The results revealed that eight cases (25.8%) harbored mutations...
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