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Intronic Variants in the MSH2 (rs2303426 and rs10179950) and PMS2 (rs2286681 and rs62456178) Genes Are Not Associated with Colorectal Cancer in Mexican Patients.

Genes - 26 Oct 2024

Rico-Méndez Manuel Alejandro, López-Ceballos Anna Guadalupe, Moreno-Ortiz José Miguel, Ayala-Madrigal María de la Luz, Gutiérrez-Angulo Melva, Ramírez-Ramírez Ruth, González-Mercado Mirna Gisel, González-Mercado Anahí

Abstract excerpt

BACKGROUND/OBJECTIVES: In the origin and development of colorectal cancer (CRC), a global public health problem, a dysfunction mismatch repair system appears to be a key factor. The objective was to determine the association of intronic variants in the MSH2 and PMS2 genes with CRC in Mexican patients. METHODS: Blood samples of 143 CRC patients and 146 reference individuals were genotyped through TaqMan®...

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Identifiers

PMID: 39596580
DOI: 10.3390/genes15111380
PMCID: PMC11594145

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