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Article

Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment.

Journal of medical genetics - 1 Jun 2005

Quehenberger F, Vasen H F A, van Houwelingen H C

Abstract excerpt

BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC) is caused by germline mutations of mismatch repair genes, usually in hMLH1 or hMSH2. All earlier studies on penetrance except one population based study were conducted in HNPCC families and did not correct for the way in which these families were ascertained. OBJECTIVE: To obtain estimates of the risk of colorectal cancer (CRC) and endometrial cancer...

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Genetic Carrier Screening

Share to Germ-Line Mutation

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Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Source

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Identifiers

PMID: 15937084
DOI: 10.1136/jmg.2004.024299
PMCID: PMC1736072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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