Article
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease.
PLoS genetics - 16 Sept 2010
Cruchaga Carlos, Kauwe John S K, Mayo Kevin, Spiegel Noah, Bertelsen Sarah, Nowotny Petra, Shah Aarti R, Abraham Richard, Hollingworth Paul, Harold Denise, Owen Michael M, Williams Julie, Lovestone Simon, Peskind Elaine R, Li Ge, Leverenz James B, Galasko Douglas, Morris John C, Fagan Anne M, Holtzman David M, Goate Alison M
Abstract excerpt
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide association studies have had some success in identifying novel genetic risk factors for AD, case-control studies are less likely to uncover genetic factors that influence progression of disease. An alternative approach to identifying genetic risk for AD is the use of quantitative traits or endophenotypes. The use of...
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