Article
An association study of common variation at the MAPT locus with late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2009
Abraham Richard, Sims Rebecca, Carroll Liam, Hollingworth Paul, O'Donovan Michael C, Williams Julie, Owen Michael J
Abstract excerpt
The MAPT gene that encodes Tau is located on chromosome 17q21, in a region, which has evolved to form two major haplotypes, H1 and H2. There is strong evidence that the H1 haplotype, and a sub-haplotype (H1C), are overrepresented and associated with increased risk for the sporadic tauopathies, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Both PSP and CBD cases display Tau pathology...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.