Article
An association study of common variation at the MAPT locus with late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2009
Abraham Richard, Sims Rebecca, Carroll Liam, Hollingworth Paul, O'Donovan Michael C, Williams Julie, Owen Michael J
Abstract excerpt
The MAPT gene that encodes Tau is located on chromosome 17q21, in a region, which has evolved to form two major haplotypes, H1 and H2. There is strong evidence that the H1 haplotype, and a sub-haplotype (H1C), are overrepresented and associated with increased risk for the sporadic tauopathies, pr...
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