Article
MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies.
Human molecular genetics - 15 Sept 2012
Trabzuni Daniah, Wray Selina, Vandrovcova Jana, Ramasamy Adaikalavan, Walker Robert, Smith Colin, Luk Connie, Gibbs J Raphael, Dillman Allissa, Hernandez Dena G, Arepalli Sampath, Singleton Andrew B, Cookson Mark R, Pittman Alan M, de Silva Rohan, Weale Michael E, Hardy John, Ryten Mina
Abstract excerpt
The MAPT (microtubule-associated protein tau) locus is one of the most remarkable in neurogenetics due not only to its involvement in multiple neurodegenerative disorders, including progressive supranuclear palsy, corticobasal degeneration, Parksinson's disease and possibly Alzheimer's disease, but also due its genetic evolution and complex alternative splicing features which are, to some extent, linked and so...
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