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Article

Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.

The Journal of experimental medicine - 7 Jul 2008

Zarrin Ali A, Goff Peter H, Senger Kate, Alt Frederick W

Abstract excerpt

Immunoglobulin heavy chain (IgH) class switch recombination (CSR) replaces the initially expressed IgH Cmu exons with a set of downstream IgH constant region (C(H)) exons. Individual sets of C(H) exons are flanked upstream by long (1-10-kb) repetitive switch (S) regions, with CSR involving a deletional recombination event between the donor Smu region and a downstream S region. Targeting CSR to specific S regions...

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Share to B-Lymphocytes
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mice, Transgenic

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Source

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Identifiers

PMID: 18541713
DOI: 10.1084/jem.20080451
PMCID: PMC2442634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.PMID 18541713Read ↗

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