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Article

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.

The EMBO journal - 3 Nov 2003

Schrader Carol E, Bradley Sean P, Vardo Joycelyn, Mochegova Sofia N, Flanagan Erin, Stavnezer Janet

Abstract excerpt

Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline, GL) Smicro segments in activated splenic B cells. Herein we examine whether mutations are also introduced into the downstream acceptor S regions prior to switch recombination, but find very...

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Share to B-Lymphocytes
Share to Base Composition
Share to DNA Nucleotidylexotransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunoglobulin Switch Region

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Share to MutS Homolog 2 Protein

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Source

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Identifiers

PMID: 14592986
DOI: 10.1093/emboj/cdg550
PMCID: PMC275407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14592986-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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