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Article

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2009

Begum Nasim A, Stanlie Andre, Doi Tomomitsu, Sasaki Yoko, Jin Hai Wei, Kim Yong Sung, Nagaoka Hitoshi, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID) introduces DNA cleavage in the Ig gene locus to initiate somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. The DNA deamination model assumes that AID deaminates cytidine (C) on DNA and generates uridine (U), resulting in DNA cleavage after removal of U by uracil DNA glycosylase (UNG). Although UNG deficiency reduces CSR efficiency to one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Primers

Share to Immunoglobulin Class Switching

Share to Polymerase Chain Reaction

Share to Recombination, Genetic

Share to Uracil-DNA Glycosidase

Source

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Identifiers

PMID: 19202054
DOI: 10.1073/pnas.0813252106
PMCID: PMC2650371

Genes

UNG
SMUG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.PMID 19202054Read ↗

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.Semantic proximity Read ↗

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.Semantic proximity Read ↗

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.Semantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.Semantic proximity Read ↗

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Semantic proximity Read ↗

Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.Semantic proximity Read ↗

Refining the Neuberger model: Uracil processing by activated B cells.Semantic proximity Read ↗

Immunoglobulin class-switch recombination deficienciesSemantic proximity Read ↗

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Semantic proximity Read ↗

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Semantic proximity Read ↗

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