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Article

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

Science (New York, N.Y.) - 19 Jan 2007

Zarrin Ali A, Del Vecchio Catherine, Tseng Eva, Gleason Megan, Zarin Payam, Tian Ming, Alt Frederick W

Abstract excerpt

Antibody class switching in activated B cells uses class switch recombination (CSR), which joins activation-induced cytidine deaminase (AID)-dependent double-strand breaks (DSBs) within two large immunoglobulin heavy chain (IgH) locus switch (S) regions that lie up to 200 kilobases apart. To test postulated roles of S regions and AID in CSR, we generated mutant B cells in which donor Smu and accepter Sgamma1...

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Source

Identifiers

PMID: 17170253
DOI: 10.1126/science.1136386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antibody class switching mediated by yeast endonuclease-generated DNA breaks.PMID 17170253Read ↗

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic HypermutationSemantic proximity Read ↗

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Semantic proximity Read ↗

Immunoglobulin class-switch recombination deficienciesSemantic proximity Read ↗

AID in Antibody Diversification: There and Back Again.Semantic proximity Read ↗

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.Semantic proximity Read ↗

Mismatch-mediated error prone repair at the immunoglobulin genes.Semantic proximity Read ↗

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Semantic proximity Read ↗

AID-initiated purposeful mutations in immunoglobulin genes.Semantic proximity Read ↗

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Semantic proximity Read ↗

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