Genetics of restless legs syndrome (RLS): State-of-the-art and future directions.

doi:10.1002/mds.21587

Article

Genetics of restless legs syndrome (RLS): State-of-the-art and future directions.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2007

Winkelmann Juliane, Polo Oli, Provini Federica, Nevsimalova Sonja, Kemlink David, Sonka Karel, Högl Birgit, Poewe Werner, Stiasny-Kolster Karin, Oertel Wolfgang, de Weerd Al, Strambi Luigi Ferini, Zucconi Marco, Pramstaller Peter P, Arnulf Isabelle, Trenkwalder Claudia, Klein Christine, Hadjigeorgiou Georgios M, Happe Svenja, Rye David, Montagna Pasquale

Abstract excerpt

Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is...

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Topics

Genetic Linkage
Humans
Inheritance Patterns
Phenotype

Genetics of restless legs syndrome (RLS): State-of-the-art and future directions.

Abstract excerpt

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