Article
Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system.
Development (Cambridge, England) - 1 Jul 2008
Wouda Rene R, Bansraj Monique R K S, de Jong Anja W M, Noordermeer Jasprina N, Fradkin Lee G
Abstract excerpt
Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. Little is known about how the kinase activity-deficient RYKs transduce Wnt signals. Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous...
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