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Article

Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.

The EMBO journal - 9 Feb 2005

Laberge Gino, Douziech Mélanie, Therrien Marc

Abstract excerpt

Connector enhancer of KSR (CNK), an essential component of Drosophila receptor tyrosine kinase/mitogen-activated protein kinase pathways, regulates oppositely RAF function. This bimodal property depends on the N-terminal region of CNK, which integrates RAS activity to stimulate RAF and a bipartite element, called the RAF-inhibitory region (RIR), which binds and inhibits RAF catalytic activity. Here, we show that...

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Identifiers

PMID: 15660123
DOI: 10.1038/sj.emboj.7600558
PMCID: PMC548663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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