Article
Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.
Genes & development - 1 Mar 1996
Cleghon V, Gayko U, Copeland T D, Perkins L A, Perrimon N, Morrison D K
Abstract excerpt
Specification of cell fates in the nonsegmented terminal regions of developing Drosophila embryos is under the control of a signal transduction pathway mediated by the receptor tyrosine kinase Torso (Tor). Here, we identify tyrosines (Y) 630 and 918 as the major sites of Tor autophosphorylation....
Topics
- Amino Acids
- Animals
- Baculoviridae
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Mutation
- Phosphopeptides
- Phosphorylation
- Precipitin Tests
- Protein Binding
- Protein Tyrosine Phosphatases
- Protein Tyrosine Phosphatases, Non-Receptor
- Receptor Protein-Tyrosine Kinases
- Recombinant Proteins
- Repressor Proteins
- Sequence Analysis
- Signal Transduction