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Article

Derailed regulates development of the Drosophila neuromuscular junction.

Developmental neurobiology - 1 Feb 2008

Liebl Faith L W, Wu Yuping, Featherstone David E, Noordermeer Jasprina N, Fradkin Lee, Hing Huey

Abstract excerpt

Neural function is dependent upon the proper formation and development of synapses. We show here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor. Mutations in both wnt5 and drl result in a significant reduction in the number of synaptic boutons. Cell-type specific rescue experiments show that wnt5 functions in the presynaptic motor neuron...

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Source

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Identifiers

PMID: 17963254
DOI: 10.1002/dneu.20562
PMCID: PMC2279185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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