Wnt-mediated axon guidance via the Drosophila Derailed receptor.

doi:10.1038/nature01522

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Article

Wnt-mediated axon guidance via the Drosophila Derailed receptor.

Nature - 10 Apr 2003

Yoshikawa Shingo, McKinnon Randall D, Kokel Michelle, Thomas John B

Abstract excerpt

In nervous systems with bilateral symmetry, many neurons project axons across the midline to the opposite side. In each segment of the Drosophila embryonic nervous system, axons that display this projection pattern choose one of two distinct tracts: the anterior or posterior commissure. Commissure choice is controlled by Derailed, an atypical receptor tyrosine kinase expressed on axons projecting in the anterior...

Topics

Animals
Axons
Cell Movement
Central Nervous System
Drosophila Proteins
Drosophila melanogaster
Phenotype
Protein Binding
Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases
Signal Transduction
Wnt Proteins
Zebrafish Proteins

Source

Open in PubMed

Identifiers

PMID: 12660735
DOI: 10.1038/nature01522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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