Article
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.
Development (Cambridge, England) - 1 Jul 2004
Xu Huansheng, Morishima Masae, Wylie John N, Schwartz Robert J, Bruneau Benoit G, Lindsay Elizabeth A, Baldini Antonio
Abstract excerpt
Dysmorphogenesis of the cardiac outflow tract (OFT) causes many congenital heart defects, including those associated with DiGeorge syndrome. Genetic manipulation in the mouse and mutational analysis in patients have shown that Tbx1, a T-box transcription factor, has a key role in the pathogenesis of this syndrome. Here, we have dissected Tbx1 function during OFT development using genetically modified mice and...
Topics
- Alleles
- Animals
- Bromodeoxyuridine
- Cell Differentiation
- Cell Division
- Coloring Agents
- DNA Mutational Analysis
- DiGeorge Syndrome
- Endothelial Cells
- Fibroblast Growth Factor 10
- Fibroblast Growth Factors