Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2008

Wamhoff Brian R, Lynch Kevin R, Macdonald Timothy L, Owens Gary K

Abstract excerpt

OBJECTIVE: The role of sphingosine-1-phosphate (S1P) receptors in acute vascular injury and smooth muscle cell (SMC) phenotypic modulation is not completely resolved. METHODS AND RESULTS: S1P receptor antagonists were used to test the hypothesis that specific S1P receptor subtypes differentially regulate SMC phenotypic modulation. In response to acute balloon injury of the rat carotid artery, S1P1/S1P3 receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to SRF gene
Share to Lysophospholipids
Share to Myocytes, Smooth Muscle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Sphingosine

Source

Open in PubMed Open full text

Identifiers

PMID: 18535287
DOI: 10.1161/ATVBAHA.107.159392
PMCID: PMC2605659

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype.PMID 18535287Read ↗

Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.Semantic proximity Read ↗

Impaired peroxisome proliferator-activated receptor-gamma contributes to phenotypic modulation of vascular smooth muscle cells during hypertension.Semantic proximity Read ↗

The early- and late stages in phenotypic modulation of vascular smooth muscle cells: differential roles for lysophosphatidic acid.Semantic proximity Read ↗

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.Semantic proximity Read ↗

Molecular mechanisms of phenotypic plasticity in smooth muscle cells.Semantic proximity Read ↗

Differential S1PR Expression and Altered Barrier, and Inflammatory Marker Levels in Human Brain Endothelial Cells Following Acute Ischemia-Reperfusion Like InjurySemantic proximity Read ↗

Regulation of smooth muscle cells in development and vascular disease: current therapeutic strategies.Semantic proximity Read ↗

Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response.Semantic proximity Read ↗

Rho GTPase, Rac1, regulates Skp2 levels, vascular smooth muscle cell proliferation, and intima formation in vitro and in vivo.Semantic proximity Read ↗

mTOR regulates vascular smooth muscle cell differentiation from human bone marrow-derived mesenchymal progenitors.Semantic proximity Read ↗

Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury.Semantic proximity Read ↗

SREBF1 maintains the contractile phenotype of vascular smooth muscle cells via PPARγ signalling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.