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Article

Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2010

Medlin Matt D, Staus Dean P, Dubash Adi D, Taylor Joan M, Mack Christopher P

Abstract excerpt

OBJECTIVE: The goals of this study were to identify the signaling pathway by which sphingosine 1-phosphate (S1P) activates RhoA in smooth muscle cells (SMC) and to evaluate the contribution of this pathway to the regulation of SMC phenotype. METHODS AND RESULTS: Using a combination of receptor-specific agonists and antagonists we identified S1P receptor 2 (S1PR2) as the major S1P receptor subtype that regulates...

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Identifiers

PMID: 20702813
DOI: 10.1161/ATVBAHA.110.209395
PMCID: PMC2930832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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