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Article

mTOR regulates vascular smooth muscle cell differentiation from human bone marrow-derived mesenchymal progenitors.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2009

Hegner Björn, Lange Maria, Kusch Angelika, Essin Kirill, Sezer Orhan, Schulze-Lohoff Eckhard, Luft Friedrich C, Gollasch Maik, Dragun Duska

Abstract excerpt

OBJECTIVE: Vascular smooth muscle cells (VSMCs) and circulating mesenchymal progenitor cells (MSCs) with a VSMC phenotype contribute to neointima formation and lumen loss after angioplasty and during allograft arteriosclerosis. We hypothesized that phosphoinositol-Akt-mammalian target of rapamycin-p70S6 kinase (PI3K/Akt/mTOR/p70S6K) pathway activation regulates VSMC differentiation from MSCs. METHODS AND RESULTS:...

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Source

Identifiers

PMID: 19074484
DOI: 10.1161/ATVBAHA.108.179457

Genes

MSC
CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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