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Article

Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures.

Gene - 15 Mar 2016

Zhu Haifeng, Li Xiaoqin, Zhang Xiaomei, Chen Deyu, Li Dan, Ren Jin, Gu Hangang, Shu Yongqian, Wang Deqiang

Abstract excerpt

BACKGROUND: Epigenetic alterations of DNA mismatch repair (MMR) genes are associated with risk of gastric cancer (GC) by causing microsatellite instability (MSI). Less understood is the association of common polymorphisms in MMR genes with the risk and MSI phenotype of GC. METHODS: A hospital-based study was conducted in China with 423 cases and 454 matched controls. Four potentially functional polymorphisms were...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26724419
DOI: 10.1016/j.gene.2015.12.050

Genes

MLH1
EXO1
MSH2
TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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