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Article

Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors.

Journal of the National Cancer Institute - 15 Nov 2000

Slattery M L, Curtin K, Anderson K, Ma K N, Ballard L, Edwards S, Schaffer D, Potter J, Leppert M, Samowitz W S

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) has been reported to occur in approximately 10%-15% of colon tumors. MSI is characterized by the presence of mutations in tandemly repeated DNA sequences known as microsatellites. Some individuals with unstable tumors have inherited mutations in mismatch repair genes, but MSI is also observed in sporadic colon cancer. It is unknown whether lifestyle factors associated...

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PMID: 11078760
DOI: 10.1093/jnci/92.22.1831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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