Article
The murine C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells.
Molecular and cellular biology - 1 Feb 1997
Almog N, Li R, Peled A, Schwartz D, Wolkowicz R, Goldfinger N, Pei H, Rotter V
Abstract excerpt
The onset of p53-dependent apoptosis results from the accumulation of damaged DNA. Recently, it was shown that the C' terminus of the p53 protein plays a central role in sensing damaged DNA. In our present study, we examined the role of the C' terminus in the induction of apoptosis. A temperature...
Topics
- Alternative Splicing
- Animals
- Apoptosis
- Bone Marrow Cells
- Cell Cycle
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA
- Gene Expression Regulation
- Kinetics
- Mice
- Mutation
- Protein Binding
- Protein Conformation
- RNA Splicing
- RNA, Messenger
- Temperature