p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

Article

p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

Oncogene - 1 Jun 1995

Guillouf C, Rosselli F, Krishnaraju K, Moustacchi E, Hoffman B, Liebermann D A

Abstract excerpt

DNA damage in proliferating mammalian cells induces a complex cellular response comprising perturbation of the cell cycle and programmed cell death. The relationship between p53-dependent and p53-independent apoptotic cell death, as well as the cell cycle checkpoints induced by DNA damaging agent...

Topics

Animals
Apoptosis
DNA Damage
G2 Phase
Gamma Rays
Hot Temperature
Mice
Mutation
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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