Article
p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.
Oncogene - 1 Jun 1995
Guillouf C, Rosselli F, Krishnaraju K, Moustacchi E, Hoffman B, Liebermann D A
Abstract excerpt
DNA damage in proliferating mammalian cells induces a complex cellular response comprising perturbation of the cell cycle and programmed cell death. The relationship between p53-dependent and p53-independent apoptotic cell death, as well as the cell cycle checkpoints induced by DNA damaging agents were explored in hematopoietic cells, using M1 myeloblastic leukemia cells, which are null for p53 expression,...
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