Article
Anti-apoptotic activity of p53 maps to the COOH-terminal domain and is retained in a highly oncogenic natural mutant.
Oncogene - 19 Aug 1999
Lassus P, Bertrand C, Zugasti O, Chambon J P, Soussi T, Mathieu-Mahul D, Hibner U
Abstract excerpt
The tumour suppressor p53 plays a complex role in the regulation of apoptosis. High levels of wild type p53 potentiate the apoptotic response, while physiological range, low levels of the protein have an anti-apoptotic activity in serum starved immortalized fibroblasts. Here we report that primary fibroblast-like cells that show normal growth control are also efficiently protected from apoptosis by the endogenous...
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