Article
Mutant p53 protein expression interferes with p53-independent apoptotic pathways.
Oncogene - 25 Jun 1998
Li R, Sutphin P D, Schwartz D, Matas D, Almog N, Wolkowicz R, Goldfinger N, Pei H, Prokocimer M, Rotter V
Abstract excerpt
Loss of normal p53 function was found frequently to interfere with response of cancer cells to conventional anticancer therapies. Since more than half of all human cancers possess p53 mutations, we decided to explore the involvement of mutant p53 in drug induced apoptosis. To further evaluate the relationship between the p53-dependent and p53-independent apoptotic pathways, and to elucidate the function of mutant...
Topics
- Animals
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Apoptosis
- Cisplatin
- Culture Media, Conditioned
- DNA Fragmentation
- Dactinomycin
- Doxorubicin
- Gamma Rays
- Gene Expression
- Genes, p53
- Growth Substances
- Mutation
- Nucleic Acid Synthesis Inhibitors