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Article

CYP2D6 polymorphism in relation to tramadol metabolism: a study of faroese patients.

Therapeutic drug monitoring - 1 Jun 2008

Halling Jónrit, Weihe Pál, Brosen Kim

Abstract excerpt

Several studies have demonstrated the impact of CYP2D6 polymorphism on the pharmacokinetics of tramadol. However, the relationship between the O-demethylation of tramadol and O-desmethyltramadol (M1) and CYP2D6 activity has not previously been investigated with tramadol in multimedicated outpatients under steady-state conditions. Hence, the aim of this study was to determine if the well documented...

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Share to Aged, 80 and over
Share to Analgesics, Opioid
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

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Share to Gene Frequency

Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 18520597
DOI: 10.1097/FTD.0b013e3181666b2f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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