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Article

SDHA is a tumor suppressor gene causing paraganglioma.

Human molecular genetics - 1 Aug 2010

Burnichon Nelly, Brière Jean-Jacques, Libé Rossella, Vescovo Laure, Rivière Julie, Tissier Frédérique, Jouanno Elodie, Jeunemaitre Xavier, Bénit Paule, Tzagoloff Alexander, Rustin Pierre, Bertherat Jérôme, Favier Judith, Gimenez-Roqueplo Anne-Paule

Abstract excerpt

Mitochondrial succinate-coenzyme Q reductase (complex II) consists of four subunits, SDHA, SDHB, SDHC and SDHD. Heterozygous germline mutations in SDHB, SDHC, SDHD and SDHAF2 [encoding for succinate dehydrogenase (SDH) complex assembly factor 2] cause hereditary paragangliomas and pheochromocytomas. Surprisingly, no genetic link between SDHA and paraganglioma/pheochromocytoma syndrome has ever been established....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20484225
DOI: 10.1093/hmg/ddq206
PMCID: PMC2901140

Genes

SDHA
SDHB
SDHC
SDHD
SDHAF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SDHA is a tumor suppressor gene causing paraganglioma.PMID 20484225Read ↗

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