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Article

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.

Cell reports - 31 Mar 2020

Morin Aurélie, Goncalves Judith, Moog Sophie, Castro-Vega Luis-Jaime, Job Sylvie, Buffet Alexandre, Fontenille Marie-Joséphine, Woszczyk Justine, Gimenez-Roqueplo Anne-Paule, Letouzé Eric, Favier Judith

Abstract excerpt

Loss-of-function mutations in the SDHB subunit of succinate dehydrogenase predispose patients to aggressive tumors characterized by pseudohypoxic and hypermethylator phenotypes. The mechanisms leading to DNA hypermethylation and its contribution to SDH-deficient cancers remain undemonstrated. We examine the genome-wide distribution of 5-methylcytosine and 5-hydroxymethylcytosine and their correlation with RNA...

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PMID: 32234487
DOI: 10.1016/j.celrep.2020.03.022

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